Mitochondrial DNA Mutations and Mitochondrial Dysfunction in Epilepsy
نویسندگان
چکیده
منابع مشابه
P8: Temporal Lobe Epilepsy and Mitochondrial Dysfunction
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملMitochondrial DNA Mutations, Pathogenicity and Inheritance
Mitochondria contain their own DNA (mtDNA), which codes for 13 proteins (all subunits of the respiratory chain complexes), 22 tRNAs and 2 rRNAs. Several mtDNA point mutations as well as deletions have been shown to be causative in well-defined mitochondrial disorders. A mixture of mutated and wild type mtDNA (heteroplasmy) is found in most of these disorders. Inheritance of mtDNA is maternal, a...
متن کاملP12: Mitochondrial Dysfunction and Oxidative Stress in Epilepsy
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متن کاملCan mitochondrial DNA mutations cause sperm dysfunction?
Very low levels of somatic mitochondrial (mt)DNA deletions have been identified in the semen of infertile men. It has been suggested that these mutations cause infertility through an effect on sperm motility, but there has been no direct evidence to show that mutant mtDNA can affect sperm function. We have carried out semen analysis on a male harbouring the A3243G mtDNA mutation and show that h...
متن کاملMitochondrial DNA, mitochondrial dysfunction, and cardiac manifestations.
Mitochondria, are the powerhouses of cells, have their own DNA (mtDNA), regulate the transport of metabolites and ions, and impact cell physiology, survival, and death. Mitochondrial dysfunction, including impaired oxidative phosphorylation, preferentially affects heart function due to an imbalance of energy supply and demand. Recently, mitochondrial mutations and associated mitochondrial dysfu...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 1999
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1157.1999.tb00897.x